Subthalamic nucleus stimulation and somatosensory temporal discrimination in Parkinsons disease
Identifieur interne : 001265 ( Main/Corpus ); précédent : 001264; suivant : 001266Subthalamic nucleus stimulation and somatosensory temporal discrimination in Parkinsons disease
Auteurs : Antonella Conte ; Nicola Modugno ; Francesco Lena ; Sabrina Dispenza ; Barbara Gandolfi ; Ennio Iezzi ; Giovanni Fabbrini ; Alfredo BerardelliSource :
- Brain [ 0006-8950 ] ; 2010-09.
Abstract
Whereas numerous studies document the effects of dopamine medication and deep brain stimulation on motor function in patients with Parkinsons disease, few have investigated deep brain stimulation-induced changes in sensory functions. In this study of 13 patients with Parkinsons disease, we tested the effects of deep brain stimulation on the somatosensory temporal discrimination threshold. To investigate whether deep brain stimulation and dopaminergic medication induce similar changes in somatosensory discrimination, somatosensory temporal discrimination threshold values were acquired under four experimental conditions: (i) medication ON/deep brain stimulation on; (ii) medication ON/deep brain stimulation off; (iii) medication OFF/deep brain stimulation on; and (iv) medication OFF/deep brain stimulation off. Patients also underwent clinical and neuropsychological evaluations during each experimental session. Somatosensory temporal discrimination threshold values obtained in patients were compared with 13 age-matched healthy subjects. Somatosensory temporal discrimination threshold values were significantly higher in patients than in healthy subjects. In patients, somatosensory temporal discrimination threshold values were significantly lower when patients were studied in medication ON than in medication OFF conditions. Somatosensory temporal discrimination threshold values differed significantly between deep brain stimulation on and deep brain stimulation off conditions only when the patients were studied in the medication ON condition and were higher in the deep brain stimulation on/medication ON than in the deep brain stimulation off/medication ON condition. Dopamine but not subthalamic nucleus deep brain stimulation restores the altered somatosensory temporal discrimination in patients with Parkinsons disease. Deep brain stimulation degrades somatosensory temporal discrimination by modifying central somatosensory processing whereas dopamine restores the interplay between cortical and subcortical structures.
Url:
DOI: 10.1093/brain/awq191
Links to Exploration step
ISTEX:8E1E7069AF35F9429AC4B8ACB0CC38194EA98F4FLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Subthalamic nucleus stimulation and somatosensory temporal discrimination in Parkinsons disease</title><author><name sortKey="Conte, Antonella" sort="Conte, Antonella" uniqKey="Conte A" first="Antonella" last="Conte">Antonella Conte</name><affiliation><mods:affiliation></mods:affiliation></affiliation><affiliation><mods:affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Modugno, Nicola" sort="Modugno, Nicola" uniqKey="Modugno N" first="Nicola" last="Modugno">Nicola Modugno</name><affiliation><mods:affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Lena, Francesco" sort="Lena, Francesco" uniqKey="Lena F" first="Francesco" last="Lena">Francesco Lena</name><affiliation><mods:affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Dispenza, Sabrina" sort="Dispenza, Sabrina" uniqKey="Dispenza S" first="Sabrina" last="Dispenza">Sabrina Dispenza</name><affiliation><mods:affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Gandolfi, Barbara" sort="Gandolfi, Barbara" uniqKey="Gandolfi B" first="Barbara" last="Gandolfi">Barbara Gandolfi</name><affiliation><mods:affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Iezzi, Ennio" sort="Iezzi, Ennio" uniqKey="Iezzi E" first="Ennio" last="Iezzi">Ennio Iezzi</name><affiliation><mods:affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name><affiliation><mods:affiliation></mods:affiliation></affiliation><affiliation><mods:affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name><affiliation><mods:affiliation></mods:affiliation></affiliation><affiliation><mods:affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: alfredo.berardelli@uniroma1.it</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8E1E7069AF35F9429AC4B8ACB0CC38194EA98F4F</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1093/brain/awq191</idno><idno type="url">https://api.istex.fr/document/8E1E7069AF35F9429AC4B8ACB0CC38194EA98F4F/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001265</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Subthalamic nucleus stimulation and somatosensory temporal discrimination in Parkinsons disease</title><author><name sortKey="Conte, Antonella" sort="Conte, Antonella" uniqKey="Conte A" first="Antonella" last="Conte">Antonella Conte</name><affiliation><mods:affiliation></mods:affiliation></affiliation><affiliation><mods:affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Modugno, Nicola" sort="Modugno, Nicola" uniqKey="Modugno N" first="Nicola" last="Modugno">Nicola Modugno</name><affiliation><mods:affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Lena, Francesco" sort="Lena, Francesco" uniqKey="Lena F" first="Francesco" last="Lena">Francesco Lena</name><affiliation><mods:affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Dispenza, Sabrina" sort="Dispenza, Sabrina" uniqKey="Dispenza S" first="Sabrina" last="Dispenza">Sabrina Dispenza</name><affiliation><mods:affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Gandolfi, Barbara" sort="Gandolfi, Barbara" uniqKey="Gandolfi B" first="Barbara" last="Gandolfi">Barbara Gandolfi</name><affiliation><mods:affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Iezzi, Ennio" sort="Iezzi, Ennio" uniqKey="Iezzi E" first="Ennio" last="Iezzi">Ennio Iezzi</name><affiliation><mods:affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name><affiliation><mods:affiliation></mods:affiliation></affiliation><affiliation><mods:affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name><affiliation><mods:affiliation></mods:affiliation></affiliation><affiliation><mods:affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: alfredo.berardelli@uniroma1.it</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2010-09">2010-09</date><biblScope unit="volume">133</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="2656">2656</biblScope><biblScope unit="page" to="2663">2663</biblScope></imprint><idno type="ISSN">0006-8950</idno></series><idno type="istex">8E1E7069AF35F9429AC4B8ACB0CC38194EA98F4F</idno><idno type="DOI">10.1093/brain/awq191</idno><idno type="ArticleID">awq191</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Whereas numerous studies document the effects of dopamine medication and deep brain stimulation on motor function in patients with Parkinsons disease, few have investigated deep brain stimulation-induced changes in sensory functions. In this study of 13 patients with Parkinsons disease, we tested the effects of deep brain stimulation on the somatosensory temporal discrimination threshold. To investigate whether deep brain stimulation and dopaminergic medication induce similar changes in somatosensory discrimination, somatosensory temporal discrimination threshold values were acquired under four experimental conditions: (i) medication ON/deep brain stimulation on; (ii) medication ON/deep brain stimulation off; (iii) medication OFF/deep brain stimulation on; and (iv) medication OFF/deep brain stimulation off. Patients also underwent clinical and neuropsychological evaluations during each experimental session. Somatosensory temporal discrimination threshold values obtained in patients were compared with 13 age-matched healthy subjects. Somatosensory temporal discrimination threshold values were significantly higher in patients than in healthy subjects. In patients, somatosensory temporal discrimination threshold values were significantly lower when patients were studied in medication ON than in medication OFF conditions. Somatosensory temporal discrimination threshold values differed significantly between deep brain stimulation on and deep brain stimulation off conditions only when the patients were studied in the medication ON condition and were higher in the deep brain stimulation on/medication ON than in the deep brain stimulation off/medication ON condition. Dopamine but not subthalamic nucleus deep brain stimulation restores the altered somatosensory temporal discrimination in patients with Parkinsons disease. Deep brain stimulation degrades somatosensory temporal discrimination by modifying central somatosensory processing whereas dopamine restores the interplay between cortical and subcortical structures.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>Antonella Conte</name><affiliations><json:null></json:null><json:string>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</json:string></affiliations></json:item><json:item><name>Nicola Modugno</name><affiliations><json:string>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</json:string></affiliations></json:item><json:item><name>Francesco Lena</name><affiliations><json:string>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</json:string></affiliations></json:item><json:item><name>Sabrina Dispenza</name><affiliations><json:string>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</json:string></affiliations></json:item><json:item><name>Barbara Gandolfi</name><affiliations><json:string>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</json:string></affiliations></json:item><json:item><name>Ennio Iezzi</name><affiliations><json:string>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</json:string></affiliations></json:item><json:item><name>Giovanni Fabbrini</name><affiliations><json:null></json:null><json:string>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</json:string></affiliations></json:item><json:item><name>Alfredo Berardelli</name><affiliations><json:null></json:null><json:string>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</json:string><json:string>E-mail: alfredo.berardelli@uniroma1.it</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Original Articles</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>subthalamic deep brain stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>somatosensory temporal discrimination</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinsons disease</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Whereas numerous studies document the effects of dopamine medication and deep brain stimulation on motor function in patients with Parkinsons disease, few have investigated deep brain stimulation-induced changes in sensory functions. In this study of 13 patients with Parkinsons disease, we tested the effects of deep brain stimulation on the somatosensory temporal discrimination threshold. To investigate whether deep brain stimulation and dopaminergic medication induce similar changes in somatosensory discrimination, somatosensory temporal discrimination threshold values were acquired under four experimental conditions: (i) medication ON/deep brain stimulation on; (ii) medication ON/deep brain stimulation off; (iii) medication OFF/deep brain stimulation on; and (iv) medication OFF/deep brain stimulation off. Patients also underwent clinical and neuropsychological evaluations during each experimental session. Somatosensory temporal discrimination threshold values obtained in patients were compared with 13 age-matched healthy subjects. Somatosensory temporal discrimination threshold values were significantly higher in patients than in healthy subjects. In patients, somatosensory temporal discrimination threshold values were significantly lower when patients were studied in medication ON than in medication OFF conditions. Somatosensory temporal discrimination threshold values differed significantly between deep brain stimulation on and deep brain stimulation off conditions only when the patients were studied in the medication ON condition and were higher in the deep brain stimulation on/medication ON than in the deep brain stimulation off/medication ON condition. Dopamine but not subthalamic nucleus deep brain stimulation restores the altered somatosensory temporal discrimination in patients with Parkinsons disease. Deep brain stimulation degrades somatosensory temporal discrimination by modifying central somatosensory processing whereas dopamine restores the interplay between cortical and subcortical structures.</abstract><qualityIndicators><score>8.5</score><pdfVersion>1.4</pdfVersion><pdfPageSize>612.68 x 790.866 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>2044</abstractCharCount><pdfWordCount>5423</pdfWordCount><pdfCharCount>36002</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>256</abstractWordCount></qualityIndicators><title>Subthalamic nucleus stimulation and somatosensory temporal discrimination in Parkinsons disease</title><genre><json:string>research-article</json:string></genre><host><volume>133</volume><pages><last>2663</last><first>2656</first></pages><issn><json:string>0006-8950</json:string></issn><issue>9</issue><genre></genre><language><json:string>unknown</json:string></language><eissn><json:string>1460-2156</json:string></eissn><title>Brain</title></host><categories><wos><json:string>CLINICAL NEUROLOGY</json:string><json:string>NEUROSCIENCES</json:string></wos></categories><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1093/brain/awq191</json:string></doi><id>8E1E7069AF35F9429AC4B8ACB0CC38194EA98F4F</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/8E1E7069AF35F9429AC4B8ACB0CC38194EA98F4F/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/8E1E7069AF35F9429AC4B8ACB0CC38194EA98F4F/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/8E1E7069AF35F9429AC4B8ACB0CC38194EA98F4F/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Subthalamic nucleus stimulation and somatosensory temporal discrimination in Parkinsons disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Oxford University Press</publisher><availability><p>OUP</p></availability><date>2010-08-26</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Subthalamic nucleus stimulation and somatosensory temporal discrimination in Parkinsons disease</title><author><persName><forename type="first">Antonella</forename><surname>Conte</surname></persName><affiliation></affiliation><affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</affiliation></author><author><persName><forename type="first">Nicola</forename><surname>Modugno</surname></persName><affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</affiliation></author><author><persName><forename type="first">Francesco</forename><surname>Lena</surname></persName><affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</affiliation></author><author><persName><forename type="first">Sabrina</forename><surname>Dispenza</surname></persName><affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</affiliation></author><author><persName><forename type="first">Barbara</forename><surname>Gandolfi</surname></persName><affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</affiliation></author><author><persName><forename type="first">Ennio</forename><surname>Iezzi</surname></persName><affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</affiliation></author><author><persName><forename type="first">Giovanni</forename><surname>Fabbrini</surname></persName><affiliation></affiliation><affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</affiliation></author><author corresp="yes"><persName><forename type="first">Alfredo</forename><surname>Berardelli</surname></persName><email>alfredo.berardelli@uniroma1.it</email><affiliation></affiliation><affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</affiliation></author></analytic><monogr><title level="j">Brain</title><idno type="pISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2010-09"></date><biblScope unit="volume">133</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="2656">2656</biblScope><biblScope unit="page" to="2663">2663</biblScope></imprint></monogr><idno type="istex">8E1E7069AF35F9429AC4B8ACB0CC38194EA98F4F</idno><idno type="DOI">10.1093/brain/awq191</idno><idno type="ArticleID">awq191</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010-08-26</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Whereas numerous studies document the effects of dopamine medication and deep brain stimulation on motor function in patients with Parkinsons disease, few have investigated deep brain stimulation-induced changes in sensory functions. In this study of 13 patients with Parkinsons disease, we tested the effects of deep brain stimulation on the somatosensory temporal discrimination threshold. To investigate whether deep brain stimulation and dopaminergic medication induce similar changes in somatosensory discrimination, somatosensory temporal discrimination threshold values were acquired under four experimental conditions: (i) medication ON/deep brain stimulation on; (ii) medication ON/deep brain stimulation off; (iii) medication OFF/deep brain stimulation on; and (iv) medication OFF/deep brain stimulation off. Patients also underwent clinical and neuropsychological evaluations during each experimental session. Somatosensory temporal discrimination threshold values obtained in patients were compared with 13 age-matched healthy subjects. Somatosensory temporal discrimination threshold values were significantly higher in patients than in healthy subjects. In patients, somatosensory temporal discrimination threshold values were significantly lower when patients were studied in medication ON than in medication OFF conditions. Somatosensory temporal discrimination threshold values differed significantly between deep brain stimulation on and deep brain stimulation off conditions only when the patients were studied in the medication ON condition and were higher in the deep brain stimulation on/medication ON than in the deep brain stimulation off/medication ON condition. Dopamine but not subthalamic nucleus deep brain stimulation restores the altered somatosensory temporal discrimination in patients with Parkinsons disease. Deep brain stimulation degrades somatosensory temporal discrimination by modifying central somatosensory processing whereas dopamine restores the interplay between cortical and subcortical structures.</p></abstract><textClass><keywords scheme="keyword"><list><item><term>Original Articles</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>subthalamic deep brain stimulation</term></item><item><term>somatosensory temporal discrimination</term></item><item><term>Parkinsons disease</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-08-26">Created</change><change when="2010-09">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/8E1E7069AF35F9429AC4B8ACB0CC38194EA98F4F/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">brain</journal-id><journal-id journal-id-type="publisher-id">brainj</journal-id><journal-title>Brain</journal-title><issn pub-type="ppub">0006-8950</issn><issn pub-type="epub">1460-2156</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.1093/brain/awq191</article-id><article-id pub-id-type="publisher-id">awq191</article-id><article-categories><subj-group><subject>Original Articles</subject></subj-group></article-categories><title-group><article-title>Subthalamic nucleus stimulation and somatosensory temporal discrimination in Parkinson’s disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Conte</surname><given-names>Antonella</given-names></name><xref ref-type="aff" rid="AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="AFF2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Modugno</surname><given-names>Nicola</given-names></name><xref ref-type="aff" rid="AFF2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lena</surname><given-names>Francesco</given-names></name><xref ref-type="aff" rid="AFF2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dispenza</surname><given-names>Sabrina</given-names></name><xref ref-type="aff" rid="AFF2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gandolfi</surname><given-names>Barbara</given-names></name><xref ref-type="aff" rid="AFF2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Iezzi</surname><given-names>Ennio</given-names></name><xref ref-type="aff" rid="AFF2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fabbrini</surname><given-names>Giovanni</given-names></name><xref ref-type="aff" rid="AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="AFF2"><sup>2</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Berardelli</surname><given-names>Alfredo</given-names></name><xref ref-type="aff" rid="AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="AFF2"><sup>2</sup></xref></contrib></contrib-group><aff id="AFF1"></aff><aff id="AFF2">1 Department of Neurological Sciences, ‘Sapienza’, University of Rome, 00185 Rome, Italy</aff><aff id="AFF3">2 Neuromed, Institute, (IRCCS), Pozzilli (IS), Italy</aff><author-notes><corresp>Correspondence to: Prof. Alfredo Berardelli, Department of Neurological Sciences, ‘Sapienza’, University of Rome, Viale dell’Università, 30, 00185 Rome, Italy E-mail: <email>alfredo.berardelli@uniroma1.it</email></corresp></author-notes><pub-date pub-type="ppub"><month>9</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>26</day><month>8</month><year>2010</year></pub-date><volume>133</volume><issue>9</issue><fpage>2656</fpage><lpage>2663</lpage><history><date date-type="received"><day>3</day><month>3</month><year>2010</year></date><date date-type="rev-recd"><day>13</day><month>5</month><year>2010</year></date><date date-type="accepted"><day>28</day><month>5</month><year>2010</year></date></history><permissions><copyright-statement>© The Author (2010). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org</copyright-statement><copyright-year>2010</copyright-year></permissions><abstract><p>Whereas numerous studies document the effects of dopamine medication and deep brain stimulation on motor function in patients with Parkinson’s disease, few have investigated deep brain stimulation-induced changes in sensory functions. In this study of 13 patients with Parkinson’s disease, we tested the effects of deep brain stimulation on the somatosensory temporal discrimination threshold. To investigate whether deep brain stimulation and dopaminergic medication induce similar changes in somatosensory discrimination, somatosensory temporal discrimination threshold values were acquired under four experimental conditions: (i) medication ON/deep brain stimulation on; (ii) medication ON/deep brain stimulation off; (iii) medication OFF/deep brain stimulation on; and (iv) medication OFF/deep brain stimulation off. Patients also underwent clinical and neuropsychological evaluations during each experimental session. Somatosensory temporal discrimination threshold values obtained in patients were compared with 13 age-matched healthy subjects. Somatosensory temporal discrimination threshold values were significantly higher in patients than in healthy subjects. In patients, somatosensory temporal discrimination threshold values were significantly lower when patients were studied in medication ON than in medication OFF conditions. Somatosensory temporal discrimination threshold values differed significantly between deep brain stimulation on and deep brain stimulation off conditions only when the patients were studied in the medication ON condition and were higher in the deep brain stimulation on/medication ON than in the deep brain stimulation off/medication ON condition. Dopamine but not subthalamic nucleus deep brain stimulation restores the altered somatosensory temporal discrimination in patients with Parkinson’s disease. Deep brain stimulation degrades somatosensory temporal discrimination by modifying central somatosensory processing whereas dopamine restores the interplay between cortical and subcortical structures.</p></abstract><kwd-group><kwd>subthalamic deep brain stimulation</kwd><kwd>somatosensory temporal discrimination</kwd><kwd>Parkinson’s disease</kwd></kwd-group></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Subthalamic nucleus stimulation and somatosensory temporal discrimination in Parkinsons disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Subthalamic nucleus stimulation and somatosensory temporal discrimination in Parkinsons disease</title></titleInfo><name type="personal"><namePart type="given">Antonella</namePart><namePart type="family">Conte</namePart><affiliation></affiliation><affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nicola</namePart><namePart type="family">Modugno</namePart><affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francesco</namePart><namePart type="family">Lena</namePart><affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sabrina</namePart><namePart type="family">Dispenza</namePart><affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Barbara</namePart><namePart type="family">Gandolfi</namePart><affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ennio</namePart><namePart type="family">Iezzi</namePart><affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giovanni</namePart><namePart type="family">Fabbrini</namePart><affiliation></affiliation><affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">Alfredo</namePart><namePart type="family">Berardelli</namePart><affiliation></affiliation><affiliation>1 Department of Neurological Sciences, Sapienza, University of Rome, 00185 Rome, Italy</affiliation><affiliation>E-mail: alfredo.berardelli@uniroma1.it</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><subject><topic>Original Articles</topic></subject><originInfo><publisher>Oxford University Press</publisher><dateIssued encoding="w3cdtf">2010-09</dateIssued><dateCreated encoding="w3cdtf">2010-08-26</dateCreated><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Whereas numerous studies document the effects of dopamine medication and deep brain stimulation on motor function in patients with Parkinsons disease, few have investigated deep brain stimulation-induced changes in sensory functions. In this study of 13 patients with Parkinsons disease, we tested the effects of deep brain stimulation on the somatosensory temporal discrimination threshold. To investigate whether deep brain stimulation and dopaminergic medication induce similar changes in somatosensory discrimination, somatosensory temporal discrimination threshold values were acquired under four experimental conditions: (i) medication ON/deep brain stimulation on; (ii) medication ON/deep brain stimulation off; (iii) medication OFF/deep brain stimulation on; and (iv) medication OFF/deep brain stimulation off. Patients also underwent clinical and neuropsychological evaluations during each experimental session. Somatosensory temporal discrimination threshold values obtained in patients were compared with 13 age-matched healthy subjects. Somatosensory temporal discrimination threshold values were significantly higher in patients than in healthy subjects. In patients, somatosensory temporal discrimination threshold values were significantly lower when patients were studied in medication ON than in medication OFF conditions. Somatosensory temporal discrimination threshold values differed significantly between deep brain stimulation on and deep brain stimulation off conditions only when the patients were studied in the medication ON condition and were higher in the deep brain stimulation on/medication ON than in the deep brain stimulation off/medication ON condition. Dopamine but not subthalamic nucleus deep brain stimulation restores the altered somatosensory temporal discrimination in patients with Parkinsons disease. Deep brain stimulation degrades somatosensory temporal discrimination by modifying central somatosensory processing whereas dopamine restores the interplay between cortical and subcortical structures.</abstract><subject><genre>Keywords</genre><topic>subthalamic deep brain stimulation</topic><topic>somatosensory temporal discrimination</topic><topic>Parkinsons disease</topic></subject><relatedItem type="host"><titleInfo><title>Brain</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0006-8950</identifier><identifier type="eISSN">1460-2156</identifier><identifier type="PublisherID">brainj</identifier><identifier type="PublisherID-hwp">brain</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>133</number></detail><detail type="issue"><caption>no.</caption><number>9</number></detail><extent unit="pages"><start>2656</start><end>2663</end></extent></part></relatedItem><identifier type="istex">8E1E7069AF35F9429AC4B8ACB0CC38194EA98F4F</identifier><identifier type="DOI">10.1093/brain/awq191</identifier><identifier type="ArticleID">awq191</identifier><accessCondition type="use and reproduction" contentType="copyright">The Author (2010). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org</accessCondition><recordInfo><recordContentSource>OUP</recordContentSource></recordInfo></mods></metadata><covers><json:item><original>true</original><mimetype>image/tiff</mimetype><extension>tiff</extension><uri>https://api.istex.fr/document/8E1E7069AF35F9429AC4B8ACB0CC38194EA98F4F/covers/tiff</uri></json:item><json:item><original>true</original><mimetype>text/html</mimetype><extension>html</extension><uri>https://api.istex.fr/document/8E1E7069AF35F9429AC4B8ACB0CC38194EA98F4F/covers/html</uri></json:item></covers><annexes><json:item><original>true</original><mimetype>image/jpeg</mimetype><extension>jpeg</extension><uri>https://api.istex.fr/document/8E1E7069AF35F9429AC4B8ACB0CC38194EA98F4F/annexes/jpeg</uri></json:item><json:item><original>true</original><mimetype>image/gif</mimetype><extension>gif</extension><uri>https://api.istex.fr/document/8E1E7069AF35F9429AC4B8ACB0CC38194EA98F4F/annexes/gif</uri></json:item><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/8E1E7069AF35F9429AC4B8ACB0CC38194EA98F4F/annexes/pdf</uri></json:item></annexes><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/8E1E7069AF35F9429AC4B8ACB0CC38194EA98F4F/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">CLINICAL NEUROLOGY</classCode><classCode scheme="WOS">NEUROSCIENCES</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001265 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 001265 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:8E1E7069AF35F9429AC4B8ACB0CC38194EA98F4F
|texte= Subthalamic nucleus stimulation and somatosensory temporal discrimination in Parkinsons disease
}}
| This area was generated with Dilib version V0.6.23. |  |